Two red cards on opening night for the Bit o’Red against Shamrock Rovers as they away side left with the points in a 2-0 win.
Pat Felon's side captured the lead in the 42nd minute when Miele's free-kick from distance curled beyond the reach of Micheál Schlingermann.
The home side had Kieran Sadlier dismissed in injury time at the end of the opening half, while Craig Roddan suffered a similar fate midway through the second half after he was shown his second yellow for a foul on Gary McCabe.
The Dublin side sealed the win in the 90th minute when North neatly tucked the ball beyond Schlingermann having been teed up by the impressive Miele.
The home side had started well and showed attacking intent early on. Two of Rovers’ eight debutants - Jimmy Keohane and Sadlier - both registered early chances for the Bit o'Red inside the first five minutes, but Hoops goalkeeper Barry Murphy was comfortable on both occasions.
Michael Drennan shot straight at Schlingermann on nine minutes, before the home side had full back Tobi Adebayo-Rowling to thank three minutes later when he cleared Drennan's goal-bound effort off the Sligo line from a dangerous Killian Brennan cross.
Miele opened the scoring three minutes from the break. His well-hit effort flew over the wall and into the top corner of the net.
Rovers’ already uphill task was made that bit more difficult one minute into injury time at the end of the first half when they were reduced to ten men as Sadlier received a straight red.
West Ham loanee Jaanai Gordon put an effort over from the angle just short of the hour as Rovers tried to get a way back into this tie.
Schlingermann got down to block away Dean Clarke's low shot with an impressive save.
On 74 minutes Rovers were reduced to nine, with Roddan dismissed for a second bookable offence after a tackle with Gary McCabe while both players challenged for a loose ball.
Shamrock Rovers substitute Gary Shaw dragged his effort wide of the Sligo goal on 81 minutes as the Tallaght outfit looked to capitalise on their numerical advantage.
North sealed the win on the stroke of full-time. Miele broke through before squaring for the unmarked North who tucked the ball into the far corner.
Rovers: Micheál Schlingermann, Tobi Adebayo-Rowling, Michael Leahy, Tim Clancy, Regan Donelon, Kieran Sadlier, Craig Roddan, Jordan Richards, Jimmy Keohane, Phil Roberts (Chris Lyons 85), Jaanai Gordon (Liam Martin 77).
Shamrock Rovers: Barry Murphy, Simon Madden, David O'Connor, Maxime Blanchard, Gavin Brennan, Gary McCabe (Gary Shaw 78), Michael Drennan, Brandon Miele, Killian Brennan, Dean Clarke (Patrick Cregg 72), Danny North.