| Date | Home | Away | |
| 05/03/2022 | Sligo Rovers FC | v | Cavan Monaghan FC |
| 12/03/2022 | Galway United FC | v | Sligo Rovers FC |
| 02/04/2022 | Dundalk FC | v | Sligo Rovers FC |
| 09/04/2022 | Sligo Rovers FC | v | Finn Harps FC |
| 16/04/2022 | Derry City FC | v | Sligo Rovers FC |
| 23/04/2022 | Sligo Rovers FC | v | Galway United FC |
| 30/04/2022 | Cavan Monaghan FC | v | Sligo Rovers FC |
| 07/05/2022 | Sligo Rovers FC | v | Derry City FC |
| 21/05/2022 | Finn Harps FC | v | Sligo Rovers FC |
| 28/05/2022 | Sligo Rovers FC | v | Dundalk FC |