| Date | Home | Away | |
| 05/03/2022 | Sligo Rovers FC | v | Shelbourne FC |
| 12/03/2022 | Peamount United FC | v | Sligo Rovers FC |
| 19/03/2022 | Sligo Rovers FC | v | Shamrock Rovers FC |
| 02/04/2022 | Dundalk FC | v | Sligo Rovers FC |
| 09/04/2022 | Donegal WL | v | Sligo Rovers FC |
| 16/04/2022 | Sligo Rovers FC | v | Athlone Town AFC |
| 23/04/2022 | Bohemian FC | v | Sligo Rovers FC |